Relaxometry and magnetic resonance imaging studies of a gadolinium-DTPA derivative containing glucoside functional groups

초록

A new type of dendritic molecule Gd-DTPA-tris-2-AEA-D2-4Glc(OH), which work as a functionalized ligand coordinating gadolinium(III) ion at the center of their frameworks with four glucose moieties on the molecular surfaces, were readily synthesized with a high yield. The structures were established by 1H, 13C NMR, and mass spectral studies. The enhanced relaxivity and tissue-selectivity of the potential contrast agent was further confirmed by MR imaging study. Thus, we envision that the dendritic modification, employed in this work, provides insight into the design of a promising candidate for novel contrast agents.