Chemical functionalization of polysaccharide for antibacterial coating applications

초록

The deterioration of surface and device function resulting from the accumulation of biological matter (i.e., proteins, cells and microorganisms), is an important issue in a wide range of fields, including biomedical devices, medical implants, marine equipment, in-/exterior materials, water purification. Thus, it is necessary to introduce functionalities on solid surfaces, which reduce the unwanted, non-specific adsorption of bioentities as well as improve the device function. Recently, it has been found that some polysaccharide coating on solid substrates is able to minimize the biofouling on the surface. For immobilization of the polysaccharide on surface by electrostatic and/or covalent interactions, it is a prerequisite to introduce chemical functional groups onto polysaccharide. Herein, we present modification of diverse substrates by adhesive polysaccharide and evaluation of the antibacterial effect on the modified surface.