Non-biofouling efficacy of polysaccharide on glass surfaces

초록

Biofouling, the deterioration of device and surface function resulting from the accumulation of bioentities (e.g., proteins, cells, and bacteria), is an important issue in a wide range of areas such as biomedical devices, biosensors, medical implants, drug delivery carriers, food industry, marine equipment, and water purification systems. To minimize the biofouling, it is prerequisite to introduce functionalities on solid surfaces, including metals and polymers, which not only minimize the unwanted, non-specific adsorption of bioentities, but also improve the device function. The formation of non-biofouling polymer on the surfaces is one of the best methods to reduce the non-specific adsorption. Thus, we coated polysaccharide as a non-biofouling polymer onto glass surface, and then functionalized the polysaccharide-coated glass through surface organic reactions. The non-biofouling efficacy of the polymer was monitored by fluorescence analysis, such as a microarray scanner.