Chemical functionalization of two-dimensional surfaces with non-biofouling polymer coating

초록

It is a prerequisite to introduce chemical functional groups onto solid surfaces (e.g., metal oxide, gold, graphene, and polymers) for the investigation of fundamental phenomena in interfacial reactions and also for many technological applications in heterogeneous catalysis, microarrays, transistors, light-emitting diodes, and sensors. In addition, Biofouling, the deterioration of device and surface function resulting from the accumulation of biological matter (i.e., proteins, cells, and microorganisms), is an important issue in a wide range of fields, including biosensors, biomedical devices, medical implants, marine equipment, water purification, and drug delivery carriers. Thus, it is necessary to introduce functionalities on solid surfaces, which minimize the unwanted, non-specific adsorption of bioentities as well as improve the device function. Recently, it has been found that non-biofouling coating on biocompatible polymers, such as poly(ethylene glycol) (PEG) derivatives and zwitterionic polymers, is one of the best methods to minimize the biofouling on solid surfaces. Herein, we present chemical functionalization of two dimensional surfaces with non-biofouling polymer coatings using surface organic reactions and surface-initiated, atom transfer radical polymerization. We believe that the strategy used herein will not only widen the application of non-biofouling coating on solid surfaces to biosensors and medical devices, but also be applicable to various other substrates which need to be functionalized spatioselectively for their applications.